Validation of serum free light chain reference ranges in primary care
نویسندگان
چکیده
منابع مشابه
Serum Free Light Chain Analysis
In healthy individuals, plasma cells originating from the bone marrow produce immunoglobulin molecules composed of two heavy chains and two light chains. There are two types of light chains in humans. The κ light chains are encoded by the immunoglobulin κ locus on chromosome 2 and λ light chains are encoded by the immunoglobulin λ locus on chromosome 22 [1]. During B lymphocyte development, the...
متن کاملA case of IgM paraproteinemia in which serum free light chain values were within reference intervals.
To the Editor: We read with interest the recent paper on the combination of serum protein electrophoresis (SPEP) and serum free light chain (FLC) assay as a potential alternative to SPEP and urine protein electrophoresis (UPEP) screening for paraproteinemia (1 ), as well as the accompanying editorial on sensitivity and specificity issues of the serum FLC assay (2 ). This assay, which first beca...
متن کاملSerum Free Light-chain Assay for the Diagnosis, Management, and Prognosis of Multiple Myeloma
In recent decades, new serum biomarkers have been developed for routine laboratory practice, such as assaying serum free light chains and more recently, assaying immunoglobulin heavy and light chain isotypes (Hevylite). In this work, we highlight the interest of new biomarkers (Hevylite Test) in the management of monoclonal gammopathies because of the technical advantages it confers and the se...
متن کاملTrimester-Specific Reference Ranges for Free Thyroxine Hormone in Iranian Pregnant Women
Introduction: Physiological changes during pregnancy affect thyroid function and also free thyroxine (FT4) assay methods. These impacts make immunoassays unreliable for detecting hypothyroxinemia during pregnancy. Due to pregnant women’s adequate consumption of iodine in Iran, reference ranges of FT4 needs to be obtained for this group. Materials and Methods: A total of 1077 Iranian pregnant wo...
متن کاملSerum free light chain assays not total light chain assays are the standard of care to assess Monoclonal Gammopathies.
The diagnosis of Multiple Myeloma is a challenge to the physician due to the non-specific symptoms (anemia, bone pain and recurrent infections) that are commonplace in the elderly population. However, early diagnosis is associated with less severe disease, including fewer patients presenting with acute renal injury, pathological fractures and severe anemia. Since 2006, the serum free light chai...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 2015
ISSN: 0004-5632,1758-1001
DOI: 10.1177/0004563215620441